Drygalski Trough is the deepest trough on the continental shelf of the western Ross Sea, Antarctica. The advances and retreats of the East and West Antarctic Ice Sheets have controlled significant environmental changes on the western Ross Sea, particularly the sediments on the shelf are closely related to ice sheet dynamics and ice shelf development since the Last Glacial Maximum (LGM). However, studies on ice sheet dynamics and glacial-marine sedimentary processes in this region since the LGM remain few. The sedimentary archives provide high- resolution record of Terra Nova Bay (TNB) polynya evolution, marine productivity changes, and ocean venti-lation since the LGM calibrated by AMS ¹⁴C  chronology. Through multi-proxy analysis of well-dated gravity cores, this study demonstrates five sedimentary units that represent discrete glacier-ocean-climate phases. Different clastic grain-size distributions and biogenic productivity signals could be recognized at the same time slice during glacial retreat due to geographic variability in sediment each core and sedimentary characteristics providing insight into the ice-sheet dynamic processes on both temporal and spatial scales. Based on different depositional environments and facies, a model of the ice sheet first thinning and then retreating was proposed in the western Ross Sea. The plausible model has been proposed to explain the retreat of the ice sheet, the collapse of ice shelf in the study area, and the formation of polynya in the western Ross Sea since the LGM. This polynya activation drove Dense Shelf Water (DSW) production, intensifying Antarctic Bottom Water (AABW) formation and ocean ventilation. Our study further indicates that the TNB polynya formation lagged eastern Ross Sea deglaciation by ~8 kyr., revealing regional asynchronicity in ice-ocean responses. This study enhances comprehension of glacier-ocean sedimentation patterns and highlights the crucial role of the Ross Sea in interglacial climate changes, with ramifications for future AABW sensitivity to Antarctic cryospheric alterations.